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李默怡

發(fā)布者:何亦橦發(fā)布時(shí)間:2020-09-08瀏覽次數(shù):9833

   


 


李默怡     副教授、博士生導(dǎo)師

 Email: [email protected]

辦公地點(diǎn)江北校區(qū)匯川樓A405


個(gè)人簡(jiǎn)介:

19969月 — 20006   學(xué)士, 微生物專業(yè),華中農(nóng)業(yè)大學(xué)

20009月 — 20036   碩士, 生化工程專業(yè),華中科技大學(xué)

20038月 — 20085   博士, 植物病理專業(yè),佛羅里達(dá)大學(xué)

20091月 — 20137   博士后,佛羅里達(dá)大學(xué)

20141月 — 20162   博士后,東南大學(xué)生命科學(xué)與技術(shù)學(xué)院

20162月至今         副教授,東南大學(xué)生命科學(xué)與技術(shù)學(xué)院



研究方向

1.   神經(jīng)發(fā)育與退行性疾病的分子機(jī)理

2.   社交障礙及社交行為相關(guān)環(huán)路的調(diào)控機(jī)制




近期代表性論文:

* co-first author; # corresponding author

1.   Peng S, Yang X, Meng S, Liu F, Lv Y, Yang H, Kong Y, Xie W, Li M#. Dual circuits originating from the ventral hippocampus independently facilitate affective empathy. Cell Rep. 2024 Jun 25;43(6):114277. doi: 10.1016/j.celrep.2024.114277.

2.   Sun Y, Li M#, Geng J, Meng S, Tu R, Zhuang Y, Sun M, Rui M, Ou M, Xing G, Johnson TK, Xie W#. Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila. Commun Biol. 2023 Oct 18;6(1):1056. doi: 10.1038/s42003-023-05428-3.

3.Peng S, Gu W, Zhu W, Zhuang Y, Yang X, Lv Y, Meng S,Xie W, Li M#. A new AAV tool for highly preferentially targeting hippocampal CA2. (2023) Mol Brain. Jun 11;16(1):50. doi: 10.1186/s13041-023-01038-6.

4.Li M*#, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W#. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477.

5.Xing G*, Li M*, Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W.  Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457

6.Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322

7.Lee KY*, Li M*, Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900

8.Li M., Liang X., and Rollins J.A. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420

9.Li M. and Rollins J.A. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538

10.  Li M. and Rollins J.A. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43


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