凌琳 教授，博士生導(dǎo)師
電話：
E-mail: [email protected]
辦公地點(diǎn)：南京市四牌樓2號，李文正樓北樓215室
個人簡介：
2004-2008安徽農(nóng)業(yè)大學(xué)生物科學(xué)學(xué)士，2009-2012特種經(jīng)濟(jì)動物學(xué)碩士，2012-2015西北工業(yè)大學(xué)和中科院分子植物科學(xué)卓越創(chuàng)新中心航空宇航科學(xué)與生物技術(shù)博士，2015-2022在美國加州大學(xué)河濱分校昆蟲系擔(dān)任博士后研究員和項(xiàng)目科學(xué)家。2022年受聘為東南大學(xué)生命科學(xué)與技術(shù)學(xué)院教授。
研究方向：害蟲發(fā)育、生殖和行為的分子調(diào)控
蚊子傳播多種危險性疾病對人類構(gòu)成巨大威脅。昆蟲在生命的各階段表現(xiàn)出形態(tài)重組和行為改變，以適應(yīng)特定階段的發(fā)育功能和環(huán)境變化。成年雌性蚊蟲進(jìn)化出的吸血繁殖策略，不僅加大了種群的擴(kuò)散能力，使之成為全球性的入侵物種；也是叮咬人類、獲取和傳播病原體的根本原因和渠道。本實(shí)驗(yàn)室以基因組編輯技術(shù)為基礎(chǔ)，整合microRNA調(diào)控、信號通路交聯(lián)、激素互作、組織通訊、體內(nèi)蛋白質(zhì)精準(zhǔn)定位和生物組學(xué)大數(shù)據(jù)的交叉研究方法，解析害蟲防控的分子靶標(biāo)和調(diào)控網(wǎng)絡(luò)。
近期代表性論文：
1. Lin Ling, Alexander S Raikhel*; Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquito Aedes aegypti. Proceedings of the National Academy of Sciences, 2021, 118 (6): e2023470118.
2. Lin Ling, Alexander S Raikhel*; Serotonin signaling regulates insulin-like peptides for growth, reproduction, and metabolism in the disease vector Aedes aegypti. Proceedings of the National Academy of Sciences, 2018, 115 (42): E9822-E9831.
3. Lin Ling, Vladimir A Kokoza, Changyu Zhang, Emre Aksoy, Alexander S Raikhel*; MicroRNA-277 targets insulin-like peptides 7 and 8 to control lipid metabolism and reproduction in Aedes aegypti mosquitoes. Proceedings of the National Academy of Sciences, 2017, 114 (38): E8017-E8024.
4. Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Xu Chen, Peng Shang, Anthony A James, Yongping Huang*, Anjiang Tan*; MiR-2 family targets awd and fng to regulate wing morphogenesis in Bombyx mori. RNA Biology, 2015, 12 (7): 742-748.
5. Lin Ling, Xie Ge, Zhiqian Li, Baosheng Zeng, Jun Xu, Abu Faiz Md Aslam, Qisheng Song, Peng Shang, Yongping Huang*, Anjiang Tan*; MicroRNA Let-7 regulates molting and metamorphosis in the silkworm, Bombyx mori. Insect Biochemistry and Molecular Biology, 2014, 53:13-21.
6. Lin Ling, Xuelan Liu, Jiaping Xu*, Zhengying You, Jingbo Zhou; Silkworm eggs: An ideal model for studying the biological effects of low energy Ar+ ion interaction in animals. Nuclear Instruments and Methods in Physics Research B, 2011, 269(18): 1997-2000.
7. Zulian Liu, Jun Xu, Lin Ling, Xingyu Luo, Dehong Yang, Xu Yang, Xiaoqian Zhang, Yongping Huang*; miR-34 regulates larval growth and wing morphogenesis by directly modulating ecdysone signaling and cuticle protein in Bombyx mori, RNA Biology, 2020, 17(9): 1342-1351.
8. Dujuan Dong, Yang Zhang, Vlastimil Smykal, Lin Ling, Alexander S Raikhel*; HR38, an ortholog of NR4A family nuclear receptors, mediates 20-hydroxyecdysone regulation of carbohydrate metabolism during mosquito reproduction, Insect Biochemistry and Molecular Biology, 2018, 96: 19-26.
9. Zulian Liu, Lin Ling, Jun Xu, Baosheng Zeng, Yongping Huang, Peng Shang, Anjiang Tan*; MicroRNA-14 regulates larval development time in Bombyx mori, Insect Biochemistry and Molecular Biology, 2018, 93: 57-65.
Bo Zhao, Keira J Lucas, Tusar T Saha, Jisu Ha, Lin Ling, Vladimir A Kokoza, Sourav Roy, Alexander S Raikhel*; MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut, PLoS Genetics, 2017, 13(8): e1006943.
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