王福龍課題組

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王福龍課題組

王福龍：副研究員

辦公地點(diǎn)：東南大學(xué)江北校區(qū) 匯川樓B305

個(gè)人簡(jiǎn)介

本科畢業(yè)于東南大學(xué)，先后獲得中國(guó)科學(xué)院大學(xué)碩士學(xué)位和英屬哥倫比亞大學(xué)博士學(xué)位，得克薩斯大學(xué)MD安德森癌癥中心和新墨西哥大學(xué)AIM中心從事博士后研究，2023年9月加入東南大學(xué)生命科學(xué)與技術(shù)學(xué)院，任副研究員。

研究方向

溶酶體損傷是一種在眾多疾病中常見(jiàn)的細(xì)胞病變，這些疾病包括病原體感染（例如新冠病毒感染）、老年性疾?。ū热缟窠?jīng)退行性疾病）、以及環(huán)境污染（包括PM2.5微粒）相關(guān)的疾病。細(xì)胞如何在內(nèi)外壓力和刺激下維持包括溶酶體在內(nèi)的內(nèi)部穩(wěn)態(tài)平衡是其最基礎(chǔ)和本質(zhì)的功能之一。本課題組旨在研究溶酶體在應(yīng)激壓力下與其他細(xì)胞器或細(xì)胞結(jié)構(gòu)的聯(lián)動(dòng)機(jī)制以及自噬在其中的作用。

代表性論文

1. Paddar MA , Wang F , Trosdal ES, Hendrix E , He Y , Salemi M, Mudd M, Jia J, Duque TLA , Javed R, Phinney B, Deretic V. Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function. eLife. 2024

2. Lee CS, Shang R, Wang F, Khayambashi P, Wang H, Araujo G, Puri K, Vlodavsky I, Hussein B, Rodrigues B. Heparanase Stimulation of Physiologic Cardiac Hypertrophy Is Suppressed After Chronic Diabetes, Resulting in Cardiac Remodeling and Dysfunction.?Diabetes. 2024 Aug 1;73(8):1300-1316.

3. Wang F, Trosdal ES, Paddar MA, Duque TLA, Allers L, Mudd M, Akepati PR, Javed R, Jia J, Salemi M, Phinney B, Deretic V. The role of ATG5 beyond Atg8ylation and autophagy. Autophagy. 2024 Feb;20(2):448-450.

4. Wang F, Peters R, Jia J, Mudd M, Salemi M, Allers L, Javed R, Duque TLA, Paddar MA, Trosdal ES, Phinney B, Deretic V. ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion. Developmental Cell. 2023 May 22;58(10):866-884.e8.

5. Deretic V, Wang F. Autophagy is part of the answer to tuberculosis. Nature Microbiology. 2023 May;8(5):762-763.

6. Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V. Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage. Autophagy. 2023 Jun;19(6):1893-1895.

7. Javed R, Jain A, Duque T, Hendrix E, Paddar MA, Khan S, Claude-Taupin A, Jia J, Allers L, Wang F, Mudd M, Timmins G, Lidke K, Rusten TE, Akepati PR, He Y, Reggiori F, Eskelinen EL, Deretic V. Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs. The EMBO Journal.2023 Jun 5;:e112845.

8. Jia J, Wang F, Bhujabal Z, Peters R, Mudd M, Duque T, Allers L, Javed R, Salemi M, Behrends C, Phinney B, Johansen T, Deretic V. Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage. The Journal of Cell Biology. 2022 Nov 7;221(11).

9. Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GPD, Javed R, Gu Y, Allers L, Peters R, Wang F, da Costa LJ, Pallikkuth S, Lidke KA, Mauthe M, Verlhac P, Uchiyama Y, Salemi M, Phinney B, Tooze SA, Mari MC, Johansen T, Reggiori F, Deretic V. ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nature Cell Biology. 2021 Aug;23(8):846-858.

10. Wang F, Pulinilkunnil T, Flibotte S, Nislow C, Vlodavsky I, Hussein B, Rodrigues B. Heparanase protects the heart against chemical or ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology. 2019 Jun; 131:29-40.

11. Wang F, Jia J, Rodrigues B. Autophagy, metabolic disease, and pathogenesis of heart dysfunction. Canadian Journal of Cardiology. 2017 Jul;33(7):850-859.

12. Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B. Heparanase overexpression induces glucagon resistance and protects animals from chemically induced diabetes. Diabetes. 2017 Jan;66(1):45-57.

13. Wang F, Jia J, Lal N, Zhang D, Chiu AP, Wan A, Vlodavsky I, Hussein B, Rodrigues B. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovascular Research. 2016 Dec;112(3):656-668.

完整文章列表：https://orcid.org/0000-0002-7083-9675

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