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邢廣林   教授，博士生導(dǎo)師

江蘇特聘教授，教育部首批海外引才專(zhuān)項(xiàng)獲得者

E-mail: [email protected]

辦公室地點(diǎn)：東南大學(xué)江北校區(qū)匯川樓A409

實(shí)驗(yàn)室地點(diǎn)：東南大學(xué)江北校區(qū)匯川樓A407

個(gè)人簡(jiǎn)介：

博士畢業(yè)于東南大學(xué)，隨后于美國(guó)奧古斯塔大學(xué)、凱斯西儲(chǔ)大學(xué)作博士后研究。2022年2月入職東南大學(xué)生命科學(xué)與技術(shù)學(xué)院，擔(dān)任教授。獲教育部引才專(zhuān)項(xiàng)、國(guó)家自然科學(xué)基金面上、江蘇特聘教授特別資助、南京市留學(xué)人員科技創(chuàng)新等項(xiàng)目支持。

研究方向：

神經(jīng)系統(tǒng)是動(dòng)物體內(nèi)最重要的系統(tǒng)之一，負(fù)責(zé)調(diào)控學(xué)習(xí)、記憶、運(yùn)動(dòng)、情感和思維等多種高級(jí)功能。其工作原理是通過(guò)神經(jīng)元之間的突觸連接，形成完整的網(wǎng)絡(luò)以實(shí)現(xiàn)信息的接收、加工和傳遞。人類(lèi)大腦約包含1000億個(gè)神經(jīng)元，每個(gè)神經(jīng)元上分布著數(shù)千到數(shù)萬(wàn)個(gè)突觸，整個(gè)大腦的突觸總數(shù)達(dá)到數(shù)萬(wàn)億。這些突觸在神經(jīng)系統(tǒng)的信息處理過(guò)程中發(fā)揮著核心作用，幾乎所有的大腦功能異常都與突觸功能的改變密切相關(guān)。

本課題組主要集中于突觸形成和神經(jīng)退行性疾病的發(fā)病機(jī)制研究。我們利用小鼠等模式生物，結(jié)合細(xì)胞生物學(xué)、分子生物學(xué)和電生理等技術(shù)，系統(tǒng)地揭示突觸形成和成熟的調(diào)控機(jī)制，以及運(yùn)動(dòng)神經(jīng)元退行性疾病的發(fā)病機(jī)制及其潛在治療策略。

代表性論文：

1.        Guanglin Xing, Hongyang Jing, Zheng Yu, Peng Chen, Hongsheng Wang, Wen-Cheng Xiong*, and Lin Mei*. Membraneless condensates by rapsyn phase separation as a platform for neuromuscular junction formation. Neuron, 2021, https://doi.org/10.1016/j.neuron.2021.04.021, Cover Story, Volume 109, Issue 12.

2.        Guanglin Xing, Wen-Cheng Xiong, and Lin Mei*. (2020). Rapsyn as a signaling and scaffolding molecule in NMJ formation and maintenance. Neuroscience Letters, 135013. doi.org/10.1016/j.neulet.2020.135013, Review.

3.        Guanglin Xing#, Hongyang Jing#, Lei Zhang, Yu Cao, Lei Li, Kai Zhao, Zhaoqi Dong, Wenbing Chen, Hongsheng Wang, Rangjuan Cao, Wen-Cheng Xiong, and Lin Mei* (2019). A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. eLife 2019; 8: e49180 DOI: 10.7554/eLife. 49180.

4.        Guanglin Xing#, Moyi Li#, Yichen Sun, Menglong Rui, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. (2018). Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction. eLife 2018; 7: e30457 DOI: 10.7554/eLife.30457.

5.        Guanglin Xing#, Guangming Gan#, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, unhai Han, and Wei Xie*. (2014). Drosophila neuroligin3 regulates neuromuscular junction development and synaptic differentiation. The Journal of Biological Chemistry 289, 31867-31877; a paper of the week.

6.        Zhibing Tan#, Heath L. Robinson#, Dong-Min Yin, Yu Liu, Fang Liu, Hongsheng Wang, Thiri W. Lin, Guanglin Xing, Lin Gan, Wen-Cheng Xiong, and Lin Mei* (2018). Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron 98, 380-393 e384.

7.        Lei Li#, Yu Cao#, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chenyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, and Lin Mei*. (2016). Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron 92, 1007-1019.

8.         Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangmin Gan, David Knight, Sheila lrene With, He Cui, Han, Junhai Han, Xiankun Zeng, Ming Fang, Gabeielle L. Boulianne, and Wei Xie*. (2011). Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction. The Journal of Neuroscience, 31, 687-699.