在线观看麻豆|麻豆短视频|2021国产麻豆剧果冻传媒入口|麻豆麻豆必出精品入口|在线观看国产欧美|免费一级欧美大片久久网|日韩精品免费一区二区|伊人色综合久久天天人守人婷|在线韩国三级中文字幕hd无码|精品成a人无码亚洲成a无码|2021久久精品99精品久久|亚洲成av人片女在线观看_一区二区无码精品_欧美日韩A V大片_日本一区二区三区在线视频

華旭  江蘇特聘教授，博士生導(dǎo)師

E-mail: [email protected]

辦公地點： 東南大學(xué)江北校區(qū)匯川樓B座406

個人簡介：

本科畢業(yè)于南京理工大學(xué)（應(yīng)用物理學(xué)專業(yè)），博士畢業(yè)于南京大學(xué)（生物信息學(xué)方向），期間在德國哥廷根大學(xué)訪學(xué)兩年。隨后于美國MD Anderson癌癥研究中心和哥倫比亞大學(xué)任博士后和副研究科學(xué)家。2024年入職東南大學(xué)生命科學(xué)與技術(shù)學(xué)院，任上崗研究員、博士生導(dǎo)師，獲江蘇省特聘教授。

研究方向：

長期專注于遺傳學(xué)與生物信息學(xué)的交叉研究，開發(fā)干濕結(jié)合的新技術(shù)，采用跨學(xué)科的方法解決遺傳學(xué)的關(guān)鍵科學(xué)問題并獲得一系列代表性成果：1）表觀遺傳記憶在親本-子代細(xì)胞之間的傳遞機制及其在細(xì)胞表型方面的重要作用。2）遺傳突變在癌癥中的作用機制。采用系統(tǒng)生物學(xué)和多組學(xué)的方法揭示了癌癥相關(guān)突變在基因調(diào)控網(wǎng)絡(luò)中的擾動機制，發(fā)現(xiàn)非編碼區(qū)上的關(guān)鍵遺傳突變的作用。3）開發(fā)基于表觀遺傳學(xué)、遺傳學(xué)的癌癥無創(chuàng)診斷新技術(shù)。已在Nature、Molecular Cell、Science Advances、Nature communications、Cancer Discovery等高水平期刊發(fā)表論文20余篇，研究成果在Nature、Cell等著名期刊上被丹麥科學(xué)院院士、歐洲科學(xué)院院士等多次引用。

代表性論文：

1. Albert Serra-Cardona^*, Xu Hua^*, Seth W. McNutt, Hui Zhou, Takenori Toda, Songtao Jia, Feixia Chu, and Zhiguo Zhang. The PCNA-Pol delta complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance. Science Advances,2024

2. Yimeng Fang^*, Xu Hua^*, Chun-Min Shan, Takenori Toda, Feng Qiao, Zhiguo Zhang, and Songtao Jia. Coordination of histone chaperones for parental histone segregation and epigenetic inheritance. Genes Development, 2024, doi:10.1101/gad.351278.123 （封面文章）

3. Xu Hua^*, Yongsheng Li^*, Sairahul R. Pentaparthi^*, Daniel J. McGrail^*, Raymond Zou^*, Li Guo^*, Aditya Shrawat, Kara M. Cirillo, Qing Li, Akshay Bhat, Min Xu, Dan Qi, Ashok Singh, Francis McGrath, Steven Andrews, Kyaw Lwin Aung, Jishnu Das, Yunyun Zhou, Alessia Lodi, Gordon B. Mills, S. Gail Eckhardt, Marc L. Mendillo, Stefano Tiziani, Erxi Wu⁺, Jason H. Huang⁺, Nidhi Sahni⁺, and S. Stephen Yi⁺. Landscape of microRNA regulatory network architecture and functional rerouting in cancer. Cancer Research, 2023, 83, 59-73

4. Zhiming Li^*, Shoufu Duan^*, Xu Hua, Xiaowei Xu, Yinglu Li, Demis Menolfi, Hui Zhou, Chao Lu, Shan Zha, Stephen P. Goff, Zhiguo Zhang⁺. Asymmetric distribution of parental H3K9me3 in S?phase silences L1 elements. Nature, 2023, vol623, 643-651

5.  Xiaowei Xu^*, Xu Hua^*, Kyle Brown, Xiaojun Ren and Zhiguo Zhang⁺. Mcm2 promotes stem cell differentiation via its ability to bind H3-H4. eLife, 2022, 11, e80917

6.  Zhiming Li^*, Xu Hua^*, Albert Serra-Cardona, Xiaowei Xu, Zhiguo Zhang⁺. Efficient and strand-specific profiling of replicating chromatin with eSPAN in mammalian cells. Nature Protocols, 2021, 16, 2698–2721

7.  Zhiming Li^*, Xu Hua^*, Albert Serra-Cardona^*, Xiaowei Xu^*, Songlin Gan, Hui Zhou, Wen-Si Yang, Chun-long Chen, Rui-Ming Xu, and Zhiguo Zhang⁺. DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands. Science Advances, 2020, Vol. 6, no. 35, eabb5820

8. Xu Hua^*, Tang Rongjun^*, Xu Xiuxiu, Wang Zhi, Xu Qi, Chen Luxiao, Wingender Edgar, Li Jie⁺, Chenyu Zhang⁺ and Wang Jin⁺. mirTrans: a resource of transcriptional regulation on microRNAs for human cell lines. Nucleic Acids Research, 2018,Volume 46, Issue D1, 4

9. Xu Hua, Luxiao Chen, Jin Wang⁺, Jie Li⁺ and Edgar Wingender⁺. Identifying cell-specific microRNA transcriptional start sites. Bioinformatics, 2016,Volume 32, Issue 16, Pages 2403–2410

10. Jie Li^*, Xu Hua^*, Martin Haubrock, Jin Wang⁺ and Edgar Wingender⁺. The architecture of the gene regulatory networks of different tissues. Bioinformatics, 2012, Volume 28, Issue 18, Pages i509–i514

招生與招聘：

歡迎具有遺傳學(xué)、表觀遺傳學(xué)、生物化學(xué)、細(xì)胞生物學(xué)、分子生物學(xué)或生物信息學(xué)等專業(yè)背景的碩士生、博士生、博士后加入本團隊，熟悉ChIP-Seq、MeDIP-Seq、CUT&RUN、單細(xì)胞測序、文庫構(gòu)建等經(jīng)驗的優(yōu)先考慮。