羅玉璇 教授，博士生導(dǎo)師
E-mail: [email protected]
辦公地點(diǎn)：東南大學(xué)江北校區(qū)匯川樓D101
個(gè)人簡(jiǎn)介：
2009 年本科畢業(yè)于四川大學(xué)（生物學(xué)基地班），2014 年在北京協(xié)和醫(yī)學(xué)院（清華大學(xué)醫(yī)學(xué)部） 獲得博士學(xué)位，2014-2017 年在重慶醫(yī)科大學(xué)附屬第二醫(yī)院從事研究工作，2017-2021 年在美國(guó)德克 薩斯大學(xué)西南醫(yī)學(xué)中心進(jìn)行博士后研究，2022 年入職東南大學(xué)，聘為東南大學(xué)青年首席教授，并入 選國(guó)家級(jí)青年人才計(jì)劃。
研究方向：心血管疾病發(fā)病機(jī)制
心血管疾病是人類(lèi)健康的“第一殺手”，嚴(yán)重影響著人們的生活質(zhì)量并威脅人類(lèi)生命健康，且發(fā) 病率逐年增加。目前關(guān)于心血管疾病的發(fā)病機(jī)制尚不完全清楚，本課題組聚焦心血管疾病的發(fā)病機(jī) 制，圍繞引起心肌肥厚和心肌損傷的信號(hào)通路和下游轉(zhuǎn)錄因子，以及心血管疾病中線粒體功能失常 的分子機(jī)制，以小鼠為模式動(dòng)物，運(yùn)用生物化學(xué)與分子生物學(xué)、細(xì)胞生物學(xué)、生物信息學(xué)等方法深 入探究影響心血管功能的關(guān)鍵因素，篩選出藥物治療靶點(diǎn)以及其它治療或預(yù)防策略，為心血管疾病 的精準(zhǔn)診治提供了新思路。
代表性論文： （* 通訊作者; # 第一作者）
1. Xiaoxuan Zhong, Xiang Wei, Yan Xu, Xuehai Zhu, Bo Huo, Xian Guo, Gaoke Feng, Zihao Zhang, Xin Feng, Zemin Fang, Yuxuan Luo *, Xin Yi * , Ding-Sheng Jiang * . The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis. Acta Pharmaceutica Sinica B, 2024;14(2):712-728.
2. Yuxuan Luo, Nan Jiang, Herman I. May, Xiang Luo, Anwarul Ferdous, Gabriele G. Schiattarella, Guihao Chen, Qinfeng Li, Chao Li, Beverly A. Rothermel, Dingsheng Jiang, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Cooperative binding of ETS2 and NFAT link Erk1/2 and calcineurin signaling in the pathogenesis of cardiac hypertrophy. Circulation. 2021;144:34-51.
3. Anwarul Ferdous, Sarvjeet Singh, Yuxuan Luo, Md. J. Abedin, Nan Jiang, Cameron E. Perry, Bret M. Evers, Thomas G. Gillette, Michael Kyba, Maria Trojanowska, Joseph A. Hill. Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial Potential of Multipotent Myogenic Progenitors. Circulation Research. 2021;129:949–964.
4. Gabriele G. Schiattarella, Francisco Altamirano, Soo Young Kim, Dan Tong, Anwarul Ferdous, Hande Piristine , Subhajit Dasgupta, Xuliang Wang, Kristin M. French, Elisa Villalobos, Stephen B. Spurgin, Maayan Waldman, Nan Jiang, Herman I. May, Theodore M. Hill, Yuxuan Luo, Heesoo Yoo, Vlad G. Zaha, Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction. Nature Communications, 2021; 12:1684.
5. Anwarul Ferdous, Zhao V. Wang, Yuxuan Luo, Dan L. Li, Xiang Luo, Gabriele G. Schiattarella, Francisco Altamirano, Herman I. May, Pavan K. Battiprolu, Annie Nguyen, Beverly A. Rothermel,Sergio Lavandero, Thomas G. Gillette, Joseph A. Hill. FoxO1–Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth. Nature Communications, 2020;11:2551.
6. Yu-Xuan Luo #, Xiaoqiang Tang # , Xi-Zhou An, Xue-Min Xie, Xiao-Feng Chen, Xiang Zhao, De-Long Hao, Hou-Zao Chen, De-Pei Liu. Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity. European Heart Journal, 2017. 38(18): p. 1389-1398.
7. Xi Jiang # , Ke-Qiong Deng # , Yu-Xuan Luo #, Ding-Sheng Jiang, Lu Gao, Xiao-Fei Zhang, Peng Zhang, Guang-Nian Zhao, Xueyong Zhu, Hongliang Li. Tumor Necrosis Factor Receptor–Associated Factor 3 Is a Positive Regulator of Pathological Cardiac Hypertrophy. Hypertension, 2015. 66(2): p. 356-67.
8. Yuan Zhang, Jing Xu, Yu-Xuan Luo, Xi-Zhou An, Ran Zhang, Guang Liu, Hongliang Li, Hou-Zao Chen, De-Pei Liu. Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to Hypertrophic Stimuli. Antioxid Redox Signal, 2014. 21(12): p. 1693-707.
9. Ding-Sheng Jiang # , Yu-Xuan Luo #, Ran Zhang # , Xiao-Dong Zhang, Hou-Zao Chen, Yan Zhang, Ke Chen, Shu-Min Zhang, Guo-Chang Fan, Peter P. Liu, De-Pei Liu, Hongliang Li. Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin. Hypertension, 2014. 63(1): p. 119-27.
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