李默怡 副教授、博士生導(dǎo)師
Email: [email protected]
辦公地點(diǎn)：江北校區(qū)匯川樓A405
個(gè)人簡(jiǎn)介：
1996年9月 — 2000年6月 學(xué)士， 微生物專(zhuān)業(yè)，華中農(nóng)業(yè)大學(xué)
2000年9月 — 2003年6月 碩士， 生化工程專(zhuān)業(yè)，華中科技大學(xué)
2003年8月 — 2008年5月 博士， 植物病理專(zhuān)業(yè)，佛羅里達(dá)大學(xué)
2009年1月 — 2013年7月 博士后，佛羅里達(dá)大學(xué)
2014年1月 — 2016年2月 博士后，東南大學(xué)生命科學(xué)與技術(shù)學(xué)院
2016年2月至今 副教授，東南大學(xué)生命科學(xué)與技術(shù)學(xué)院
研究方向：
1. 神經(jīng)發(fā)育與退行性疾病的分子機(jī)理
2. 社交障礙及社交行為相關(guān)環(huán)路的調(diào)控機(jī)制
近期代表性論文：
* co-first author; # corresponding author
1. Peng S, Yang X, Meng S, Liu F, Lv Y, Yang H, Kong Y, Xie W, Li M#. Dual circuits originating from the ventral hippocampus independently facilitate affective empathy. Cell Rep. 2024 Jun 25;43(6):114277. doi: 10.1016/j.celrep.2024.114277.
2. Sun Y, Li M#, Geng J, Meng S, Tu R, Zhuang Y, Sun M, Rui M, Ou M, Xing G, Johnson TK, Xie W#. Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila. Commun Biol. 2023 Oct 18;6(1):1056. doi: 10.1038/s42003-023-05428-3.
3.Peng S, Gu W, Zhu W, Zhuang Y, Yang X, Lv Y, Meng S,Xie W, Li M#. A new AAV tool for highly preferentially targeting hippocampal CA2. (2023) Mol Brain. Jun 11;16(1):50. doi: 10.1186/s13041-023-01038-6.
4.Li M*#, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W#. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477.
5.Xing G*, Li M*, Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W. Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457
6.Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322
7.Lee KY*, Li M*, Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900
8.Li M., Liang X., and Rollins J.A. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420
9.Li M. and Rollins J.A. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538
10. Li M. and Rollins J.A. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43
