耿俊華，副研究員，碩士生導(dǎo)師
Email：[email protected]
辦公地點(diǎn)：南京市浦口區(qū)東大路2號(hào)，匯川院A405
個(gè)人簡(jiǎn)介：
本科畢業(yè)于安徽農(nóng)業(yè)大學(xué)（生物技術(shù)），碩士畢業(yè)于東南大學(xué)（遺傳學(xué)），博士畢業(yè)于北京師范大學(xué)（細(xì)胞生物學(xué)），隨后于美國(guó)南加州大學(xué)接受博士后訓(xùn)練。2018 年入職東南大學(xué)生命科學(xué)與技術(shù)學(xué)院。
研究方向：突觸結(jié)構(gòu)與功能，及其與疾病的關(guān)聯(lián)
神經(jīng)元之間通過突觸相互聯(lián)結(jié)來傳遞信息。解析突觸蛋白在突觸中的組織架構(gòu)、以及在神經(jīng)活動(dòng)過程中的動(dòng)態(tài)特性，是解密大腦奧秘的一個(gè)關(guān)鍵環(huán)節(jié)。神經(jīng)活動(dòng)調(diào)節(jié)突觸局部蛋白質(zhì)合成、組裝，誘導(dǎo)突觸蛋白修飾，從而調(diào)控突觸功能并使神經(jīng)回路對(duì)外界刺激產(chǎn)生動(dòng)態(tài)響應(yīng)。我們主要運(yùn)用遺傳學(xué)，生物化學(xué)與分子生物學(xué)，細(xì)胞生物學(xué)和電子顯微鏡等方法與手段，通過對(duì)突觸內(nèi)蛋白質(zhì)的修飾調(diào)控，蛋白質(zhì)機(jī)器的組裝，以及突觸結(jié)構(gòu)與功能的研究，揭示神經(jīng)活動(dòng)對(duì)突觸發(fā)育和可塑性的調(diào)控機(jī)理，為神經(jīng)可塑性相關(guān)疾病的預(yù)防和治療提供理論依據(jù)。
主要代表性論文：
1. Gan Guangming*, Chen Mei, Yu Qinfeng, Gao Xiang, Zhang Chenchen, Sheng Qingyuan, Xie Wei, Geng Junhua*. Neurexin and neuroligins jointly regulate synaptic degeneration at the Drosophila neuromuscular junction based on TEM studies. Front Cell Neurosci,2023,17:1257347.2. Gan Guangming*; Chen Mei; Zhang Chenchen; Xie Wei; Geng Junhua*. Improved analysis method of neuromuscular junction in Drosophila larvae by transmission electron microscopy. Anat Sci Int, 2021, https://doi.org/10.1007/s12565-021-00635-6
3. Peng Yi-Jheng#; Geng Junhua#; Wu Ying; Pinales Cristian; Langen Jennifer; Chang Yen-Ching; Buser Christopher; Chang Karen T.*. Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin, J Cell Biol, 2021, 220 (12): e202011028. https://doi.org/10.1083/jcb.202011028
4. Gan Guangming*; Geng Junhua; Chen chen; Mou Yang; Xie Wei. Neurexin and Neuroligins maintain the balance of ghost boutons and satellite boutons at the Drosophila neuromuscular junction, Front. Neuroanat, 2020, 14:19. doi: 10.3389/fnana.2020.00019
5. Lee Joo Yeun; Geng Junhua; Lee Juhyun; Wang Andrew R.; Chang Karen T. *. Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at the Drosophila Neuromuscular Junction. The Journal of Neuroscience, 2017, 37:3246-3263.
6. Geng Junhua#; Xia Lu#; Li Wanjie; Zhao Changqi; Dou Fei*. Cycloheximide Treatment Causes a ZVAD-Sensitive Protease-Dependent Cleavage of Human Tau in Drosophila Cells. Journal of Alzheimer's Disease, 2016, 49:1161-1168.
7. Geng Junhua#; Wang Liping#; Lee Joo Yeun; Chen Chun-Kan; Chang Karen T.*. Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools. The Journal of Neuroscience, 2016, 36:8882-8894.
8. Geng Junhua; Xia Lu; Li Wanjie; Dou Fei*. The C-terminus of tau protein plays an important role in its stability and toxicity. Journal of Molecular Neuroscience, 2015, 55:251-259.
發(fā)表文章完整列表：https://orcid.org/0000-0001-5817-8870
真誠(chéng)歡迎各位志同道合的同學(xué)加入我們
