楊屹 上崗副研究員
Email: [email protected]
辦公地點(diǎn)：東南大學(xué)四牌樓校區(qū)李文正樓南207
教育及工作經(jīng)歷：
2023.8 — 現(xiàn)在 東南大學(xué)生命科學(xué)與技術(shù)學(xué)院副研究員
2023.2 — 2023.7 香港中文大學(xué)（深圳）訪問學(xué)者
2020.1 — 2023.1 新加坡國立大學(xué)Duke-NUS醫(yī)學(xué)院博士后
2015.9 — 2020.1 上海財(cái)經(jīng)大學(xué)統(tǒng)計(jì)學(xué)
2012.9 — 2015.7 首都經(jīng)濟(jì)貿(mào)易大學(xué)統(tǒng)計(jì)學(xué)
2008.9 — 2012.7 安徽大學(xué)數(shù)學(xué)與應(yīng)用數(shù)學(xué)
研究方向：
生物統(tǒng)計(jì)學(xué)，生物信息學(xué)。
研究方向一，空間轉(zhuǎn)錄組數(shù)據(jù)的分析和建模，主要是構(gòu)建統(tǒng)計(jì)學(xué)模型來分析空間轉(zhuǎn)錄組數(shù)據(jù)，提高空間轉(zhuǎn)錄組數(shù)據(jù)的質(zhì)控，聚類和標(biāo)注的效果。
研究方向二，GWAS數(shù)據(jù)的分析和建模，主要是構(gòu)建統(tǒng)計(jì)學(xué)模型來分析GWAS數(shù)據(jù)，探索和疾病和SNP之間的相關(guān)性。
在研項(xiàng)目：
國家自然科學(xué)基金青年基金項(xiàng)目，2025-2027年（無參考數(shù)據(jù)的二維/三維的空間轉(zhuǎn)錄組數(shù)據(jù)的反卷積研究，項(xiàng)目負(fù)責(zé)人）
代表作：（*代表共同一作； #代表通訊作者）
1) Peng Xie, Xu Jiang, Jingjing He, Qingyun Pan, Xianfa Yang, Yanying Zheng, Wenli Fan, Chen Wu, Weiheng Zheng, Ke Fang, Shuhan Si, Shiqi Zhu, Yi Yang, Tao P Zhong, Zhongzhou Yang, Ke Wei, Wei Xie, Naihe Jing#, Zhuojuan Luo#, Chengqi Lin#. Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics [J]. eLife 2024
2) Guangyao Mao*, Yi Yang*, Zhuojuan Luo#, Chengqi Lin#，Peng Xie#. SpatialQC: transcriptome data automated quality control for spatial transcriptome data [J]. Bioinformatics, 2024: btae458.
3) Xingjie Shi*#, Yi Yang*, Xiaohui Ma, Yong Zhou, Zhenxing Guo, Chaolong Wang, Jin Liu#. Probabilistic cell/domain-type assignment of spatial transcriptomics data with SpatialAnno[J]. Nucleic Acids Research, 2023, 51(22): e115-e115.
4) Mai Chan Lau*, Yang Yi*, Denise Goh*, Chun Chau Lawrence Cheung*, Benedict Tan Jeffrey Chun Tatt Lim, Craig Ryan Joseph, Felicia Wee, Justina Nadia Lee, Xinru Lim, Chun Jye Lim, Wei Qiang Leow, Jing Yi Lee , Cedric Chuan Young Ng , Hamed Bashiri , Peng Chung Cheow, Chun Yip Chan, Ye Xin Koh, Thuan Tong Tan, Shirin Kalimuddin, Wai Meng David Tai , Jia Lin Ng , Jenny Guek-Hong Low, Tony Kiat Hon Lim Jin Liu and Joe Poh Sheng Yeong ”Case report: Understanding the impact of persistent tissue-localization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidity.” Frontiers in Immunology) 2022, 13: 5376.
5) Yi Yang*, Xingjie Shi*, WeiLiu, Qiu zhong Zhou, Mai Chan Lau, Jeffrey Chun Tatt Lim, Lei Sun,Cedric Chuan Young Ng, Joe Yeong, Jin Liu. ”SC-MEB: spatial clustering with hidden Markov random field using empirical Bayes.” Briefings in Bioinformatics. 2022, 23(1).
6) Yi Yang*, Kar-Fu Yeung*, Jin Liu. ”CoMM-S4: A Collaborative Mixed Model Using Summary-Level eQTL and GWAS Datasets in Transcriptome-Wide Association Studies.” Frontiers in Genetics, 12 (2021).
7) Yi Yang, Xingjie Shi,Yuling Jiao, Jian Huang, Min Chen, Xiang Zhou, Lei Sun, Xinyi Lin, Can Yang, Jin Liu. ”CoMM-S2: a collaborative mixed model using summary statistics in transcriptome-wide association studies. ”Bioinformatics, 2020, 36(7): 2009-2016.
8) Yi Yang, Mingwei Dai, Jian Huang, Xinyi Lin, Can Yang, Min Chen & Jin Liu. ”LPG: A four-group probabilistic approach to leveraging pleiotropy in genome-wide association studies.” BMC genomics, 2018, 19(1): 1-11.
